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Research Journal of Engineering and Technology
ISSN: 2321-581X(Online), 0976-2973(Print)
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A Computational Analysis to Study the Application of Lipid Nanotechnology in the Field of Drug Delivery to Treat Liver Diseases
Praveen Kumar P.K.
Karthick J.1, Praveen Kumar P.K.2
1Final Year, Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur
2Assistant Professor, Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur
The Present Study is to analyse the targeted delivery of Ursodiol, a drug used in the treatment of Primary Sclerosing Cholangitis (PSC) using Lipid Bilayer Nano-Particles or Solid Lipid Nano Particles(SLNPs) which is taken for in-silico binding studies with various 4 different liver receptors. 3 Solid Lipid Nano Particles are chosen and Binding Efficiency of the Drug with Solid Lipid Nano Particles are Studied Using DFT Analysis and FEM Analysis. It was seen that the complete drug binding is seen in Small Unilamellar Vessicle (SUV). Chosen Liver Receptors with Ursodiol of the SUV are checked for binding studies using AutoDock 4. The Study revealed that Liver X Receptor a has a greater efficiency in binding with the Solid Lipid Nano Particles.
Ursodiol, Solid Lipid Nano Particles, Small Unilamellar Vessicle, Liver Receptors.
Karthick J., Praveen Kumar P.K. A Computational Analysis to Study the Application of Lipid Nanotechnology in the Field of Drug Delivery to Treat Liver Diseases. Research J. Engineering and Tech. 4(4): Oct.-Dec., 2013 page 284-287.
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